CIO Tomorrow

Forge Biologics

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Forge Biologics was created to solve a manufacturing bottleneck in the gene therapy industry, with a mission to make therapeutics available to patients faster. With an innovative hybrid business model that encompasses manufacturing for external clients plus internal innovations, Forge capitalized on Ohio’s strength in manufacturing, and combined a “big idea” hybrid model with support from Ohio’s top VC firm to launch a startup that has already secured $160 million and has put Forge on track to become the largest producer of dedicated AAV manufacturing in the world in the next few years.

+ About Forge Biologics:

Forge is a gene therapy development engine, enabling access to life changing discoveries by bringing them from concept to reality. Our partners and clients are other innovators in the gene therapy community: scientists, physicians, biotech and pharma companies and patient groups. The Company was co-founded in 2020 by Timothy J. Miller, Ph.D., Erandi De Silva, Ph.D., and Jaysson Eicholtz. It launched with $40 million of VC investments in July 2020, raised during global pandemic. Nine months later in April 2021, its leadership secured $120 million—the largest Series B fundraise in Ohio’s history, independent of industry (according to PitchBook). Forge has seen rapid growth: from 3 co-founders in July 2020, to 110+ team members in August 2021, and is expected to grow to over 200 by the end of 2022.

Gene therapy manufacturing has increased significantly in recent years, yet it is a complex, costly and long process which requires significant investments of capital, time and expertise. Forge was created from the founders’ desire to provide novel gene therapies to patients suffering from rare diseases, and to help alleviate the manufacturing bottleneck for gene therapies. The Company embraces a unique hybrid business model: Forge is a gene therapy-focused contract development and manufacturing organization (CDMO), and also has its own pipeline of novel therapeutics. It is poised to become the largest dedicated AAV manufacturer in the world in the next few years.


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